Dongheon Lee



I am a Ph.D. candidate at Artie McFerrin Department of Chemical Engineering at Texas A&M University, College Station, TX.
Education

Research Interests

Journal Publications
  1. D. Lee, A. Jayaraman, J. S. Kwon, "Inference of Parameter Distributions in Heterogeneous Intracellular Biological Processes through Dimension Reduction and Surrogate Model Development," Submitted.
  2. H.-K. Choi, D. Lee, A. Singla, H.-J. Wu, J.S. Kwon, "A theoretical approach to investigate lectin-glycan recognition principle on cell membrane surfaces," Glycobiology, 2019, 29(5), 397-408. [Link]
  3. D. Lee, A. Jayaraman, J. S. Kwon, “Identification of a time-varying intracellular signaling model through data clustering and parameter selection: application to NFκB signaling pathway induced by LPS in the presence of BFA,” IET Systems Biology, 2019, 13(4), 169-179. [Link]
  4. D. Lee, A. Mohr, J.S. Kwon, H.-J. Wu, "Kinetic Monte Carlo modeling of multivalent binding of CTB proteins with GM1 receptors," Computers & Chemical Engineering, 2018, 118, 283-295. [Link]
  5. N.C. Worstell, A. Singla, P. Saenkham, T. Galbadage, P. Sule, D. Lee, A. Mohr, J.S. Kwon, J. D. Cirillo, H.-J. Wu, "Hetero-Multivalency of Pseudomonas aeruginosa Lectin LecA Binding to Model Membranes," Scientific Reports, 2018, 8(1), 8419. [Link]
  6. D. Lee, A. Singla, H.-J. Wu, J.S. Kwon, "An Integrated Numerical and Experimental Framework for Modeling of CTB and GD1b Ganglioside Binding Kinetics," AIChE Journal, 2018, 64(11), 3882-3893. [Link]
  7. D. Lee, Y. Ding, A. Jayaraman, J.S. Kwon, "Mathematical Modeling and Parameter Estimation of Intracellular Signaling Pathway: Application to LPS-induced NFκB Activation and TNFα Production in Macrophages," Processes, 2018, 6(3), 21. [Link]
  8. B.K. Chethana, D. Lee, S.H. Mushrif, "First principles investigation into the metal catalysed 1, 2 carbon shift reaction for the epimerization of sugars," Journal of Molecular Catalysis A: Chemical, 2015, 410, 66-73. [Link]

Conference Proceedings
  1. D. Lee, A. Jayaraman, J.S. Kwon, "Identification of Heterogeneous Parameters in an Intracellular Reaction Network from Population Snapshot Measurements through Sensitivity Analysis and Neural Network," Proceedings of the 8th IFAC Conference on Foundations of Systems Biology in Engineering, Valencia, Spain, 2019 (To be appeared).
  2. D. Lee, Y. Ding, A. Jayaraman, J.S. Kwon, "Integrative Approach to Extract the Single-cell Dynamics of LPS-induced NFκB Signal Pathway through Flow Cytometry Measurements and Parameter Estimation," Proceedings of the American Control Conference, 1975-1980, Milwaukee, Wisconsin, 2018. [Link]
  3. D. Lee, A. Singla, H.-J. Wu, J.S. Kwon, "Dynamic Modeling of Binding Kinetics Between GD1b Ganglioside and Cholera Toxin Subunit B," Proceedings of the American Control Conference, 1999-2004, Milwaukee, Wisconsin, 2018. [Link]
  4. D. Lee, A. Mohr, J.S. Kwon, H.-J. Wu, A. Singla, "Stochastic Modelling of CTB-receptor Binding Kinetics," Proceedings of 13th International Symposium on Process Systems Engineering - PSE 2018, Computer-Aided Chemical Engineering, 44, 2143-2148, San Diego, California, 2018. [Link]

Oral Presentations
  1. D. Lee, A. Jayaraman, and J. S. Kwon, “Estimation of Probability Density Functions of Model Parameters for a Heterogeneous Population with Neural Network: Application to TNFα Signaling Pathway,” AIChE 2019 Annual Meeting, paper 195h, Orlando, Florida 2019.
  2. D. Lee, Y. Ding, A. Jayaraman, and J. S. Kwon, “Integrative Analysis of Free Fatty Acid-Induced NFκB Activation in Macrophages: A Step Towards the Quantitative Understanding of Inflammation Induced By Obesity,” AIChE 2019 Annual Meeting, paper 158g, Orlando, Florida 2019.
  3. D. Lee, A. Jayaraman, and J. S. Kwon, "Construction of a Semi-Stochastic Intracellular Signaling Model via Global SensitivityAnalysis and Probability Density Estimation," Student Research Week 2019, Texas A&M University, College Station, Texas 2019.
  4. D. Lee, A. Mohr, H.-J. Wu and J. S. Kwon, "Stochastic Modeling of CTB-GM1 Binding Kinetics," 5th Annual ChEGSA Research Symposium, Texas A&M University, College Station, 2018.
  5. D. Lee, J.L. Dial III, J.S. Kwon, A. Singla and H. J. Wu, “Stochastic Modeling of CTB-GM1 Binding Mechanisms,” AIChE 2017 Annual Meeting, paper 254e, Minneapolis, Minnesota, 2017 (Selected as Best Presentation in Session 254).
  6. D. Lee, Y. Ding, A. Jayaraman, and J. S. Kwon, “Modeling LPS-Induced TNF-α Production in Macrophages,” AIChE 2017 Annual Meeting, Minneapolis, paper 343a, Minnesota 2017.
  7. D. Lee, A. Singla, H.-J. Wu and J. S. Kwon, “Investigating Cholera Toxin Binding Mechanism with Gangliosides Via Kinetic Modeling and Experimental Measurements,” AIChE 2017 Annual Meeting, paper 416f, Minneapolis, Minnesota, 2017.
  8. D. Lee, Y. Ding, A. Jayaraman and J.S. Kwon, “Developing a Stochastic Model of LPS-Induced TNF-α Production in Macrophages,” AIChE 2016 Annual Meeting, paper 341d, San Francisco, California, 2016.

Poster Presentations
  1. D. Lee, A. Jayaraman, and J. S. Kwon, “Time-Varying Model Identification of Nonlinear Systems with Partially Known Model Structure: Application to NFκB Signaling pathway induced by LPS and BFA,” AIChE 2019 Annual Meeting, paper 371p, Orlando, Florida 2019.
  2. D. Lee, A. Jayaraman, and J. S. Kwon, "Construction of a Semi-Stochastic Intracellular Signaling Model via Global SensitivityAnalysis and Probability Density Estimation," 6th Annual ChEGSA Research Symposium, Texas A&M University, College Station, Texas 2019 (3rd Place in Best Poster Presentation Award).
  3. D. Lee, A. Jayaraman, and J. S. Kwon, “Construction of a Semi-Stochastic Intracellular Signaling Model Via Global Sensitivity Analysis and Probability Density Estimation,” AIChE 2018 Annual Meeting, paper 182i, Pittsburgh, Pennsylvania, 2018.
  4. D. Lee, H. K. Choi, H.-J. Wu, and J. S. Kwon, "Investigating LecA Binding Mechanisms with a Cellular Membrane Containing Multiple Types of Receptors Via Kinetic Monte Carlo Simulation,” AIChE 2018 Annual Meeting, paper 182l, Pittsburgh, Pennsylvania, 2018.
  5. D. Lee, Y. Ding, A. Jayaraman, and J. S. Kwon, "Integrative Approach to Model Average Single-cell Dynamics of LPS-induced TNF-α in Macrophages," 2017 Korean-American Scientists and Engineers Association (KSEA) West Gulf Coast Regional Conference, Houston, Texas 2017.
  6. D. Lee, Y. Ding, A. Jayaraman, and J. S. Kwon, "Modeling LPS-induced TNF-α Production in Macrophages," National Labs Day, Texas A&M University, College Station, Texas 2017.
  7. D. Lee, Y. Ding, A. Jayaraman, and J. S. Kwon, “Modeling LPS-induced TNF production in macrophages,” 2017 ENG-LIFE Workshop, College Station, Texas, 2017.
  8. D. Lee, Y. Ding, A. Jayaraman, and J. S. Kwon, “Modeling LPS-induced TNF production in macrophages,” 2017 Texas System Day, College Station, Texas, 2017.
  9. D. Lee, Y. Ding, A. Jayaraman, and J. S. Kwon, "Modeling LPS-induced TNF-α Production in Macrophages," 4th Annual ChEGSA Research Symposium, Texas A&M University, College Station, Texas 2017.
  10. D. Lee, Y. Ding, A. Jayaraman, and J. S. Kwon, "Modeling LPS-induced TNF-α Production in Macrophages," 2016 KSEA West Gulf Coast Regional Conference, Houston, Texas 2016.